The role of minerals in the optimal functioning of the immune system

C Weyh, K Krüger, P Peeling, L Castell - Nutrients, 2022 - mdpi.com
Minerals fulfil a wide variety of functions in the optimal functioning of the immune system.
This review reports on the minerals that are essential for the immune system's function and …

[HTML][HTML] Nutrition, immunity and COVID-19

PC Calder - BMJ nutrition, prevention & health, 2020 - ncbi.nlm.nih.gov
The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi,
parasites). To deal with this array of threats, the immune system has evolved to include a …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Metabolic coordination of T cell quiescence and activation

NM Chapman, MR Boothby, H Chi - Nature reviews immunology, 2020 - nature.com
Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

Iron metabolism and immune regulation

S Ni, Y Yuan, Y Kuang, X Li - Frontiers in immunology, 2022 - frontiersin.org
Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly
controlled in the body, disturbance of iron homeostasis under certain type of condition leads …

Anemia of inflammation

G Weiss, T Ganz, LT Goodnough - Blood, The Journal of the …, 2019 - ashpublications.org
Anemia of inflammation (AI), also known as anemia of chronic disease (ACD), is regarded
as the most frequent anemia in hospitalized and chronically ill patients. It is prevalent in …

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection

R Bellmann-Weiler, L Lanser, R Barket… - Journal of clinical …, 2020 - mdpi.com
Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients
present with systemic inflammation, we studied the prevalence and predictive value of …

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …

NUPR1 is a critical repressor of ferroptosis

J Liu, X Song, F Kuang, Q Zhang, Y Xie, R Kang… - Nature …, 2021 - nature.com
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …