Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Emerging and re-emerging illnesses will probably present a new hazard of infectious
diseases and have fostered the urge to research new antiviral agents. Most of the antiviral …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The consistency of the associations between gastric mucosal microbiome and gastric cancer
across studies remained unexamined. We aimed to identify universal microbial signatures in …

Indole derivatives have become an important class of compounds in medicinal chemistry,
recognized for their wide-ranging biological activities and therapeutic potential. This review …

Physiological changes in GTP levels in live cells have never been considered a regulatory
step of RAC1 activation because intracellular GTP concentration (determined by …

An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19
respiratory disease, has infected over 290,000 people since the end of 2019, killed over …

Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation
and an important factor for immune regulation. The purine de novo pathway and salvage …

Background & Aims We have shown previously that mycophenolate mofetil (MMF) might be
used as first-line treatment instead of azathioprine (AZA) in individuals with autoimmune …

Colorectal cancer, a malignant tumor with high mortality, has a poor prognosis due to drug
resistance and toxicity in clinical surgery and chemotherapy. Thus, finding safer and more …