CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a
complex multifactorial chronic disease. Here, we present an overview of the current research …

CD8+ lymphocytes are adaptive immunity cells with the particular function to directly kill the
target cell following antigen recognition in the context of MHC class I. In addition, CD8+ T …

Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-
inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 …

Immunological memory is critical for immune protection, particularly at epithelial sites, which
are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ …

T cells differentiate into highly diverse subsets and display plasticity depending on the
environment. Although lymphocytes are key mediators of inflammation, functional …

Inflammatory diseases are often chronic and recurrent, and current treatments do not
typically remove underlying disease drivers. T cells participate in a wide range of …

Tissue‐resident memory T cells (TRMs) are plentiful in the memory T cell pool and persist in
barrier sites without recirculating. Increasing evidence has shown that some kinds of CD8+ …

The human intestine contains a complex network of innate and adaptive immune cells that
provide protective immunity. The dysfunction of this network may cause various chronic …

The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been
correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we …

Lympho-epithelial interactions between intestinal T resident memory cells (Trm) and the
epithelium have been associated with inflammatory bowel disease (IBD) activity. We …