Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …

Targeted protein degradation (TPD) mediates protein level through small molecule induced
redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

As epigenetic therapies continue to gain ground as potential treatment strategies for cancer
and other diseases, compounds that target histone lysine methylation and the enzyme …

Bone remodeling is a continuous and dynamic process of bone formation and resorption to
maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages …

Simple Summary Enhancer of zeste homolog 2 (EZH2) modifies the trimethylation of Lys-27
of histone 3, affecting downstream target genes' expression. It was reported that EZH2 is …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

Interrupting the embryonic ectoderm development (EED)–H3K27me3 interaction represents
a promising strategy to allosterically inhibit polycomb repressive complex 2 (PRC2) for …

Background It is imperative to develop novel therapeutics to overcome chemoresistance, a
significant obstacle in the clinical management of prostate cancer (PCa) and other cancers …