Mexico presents a complex population diversity integrated by Mexican indigenous (MI)(7%
of Mexico's population) and Mexican mestizos (MMs). This composition highlights the …

The identification and characterization of pharmacogenetic variants in Latin American
populations is still an ongoing endeavor. Here, we investigated SNVs on genes listed by the …

Many lines of evidence suggest that warfarin dosing variability is significantly associated
with cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 …

Aim Type 2 diabetes (T2D), as a major cause of morbidity and mortality, is predicted to have
a prevalence of 629 million by 2045. As diabetic patients show considerable inter-individual …

Background Thiopurines are effectively prescribed for immune and oncology diseases but
their toxicity leads to severe myelosuppression. Therefore, TPMT genetic variants have been …

Purpose Information on genetic variants that affect the pharmacokinetics and
pharmacodynamics (PK/PD) of drugs in different populations from Mexico is still an ongoing …

Aim: To determine allele and genotype frequencies of genes influencing anti-epileptic drug
therapy in Mexican-Mestizo (MM) healthy volunteers, and to evaluate whether these are …

Aims: Polymorphisms in the CYP2C9 and CYP2C19 genes confer potential risk for specific
adverse drug reactions and therapeutic effect failure. Their frequencies differ among ethnic …

Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred
form. It is well known that despite its efficacy, coumarins show a high variability for dose …

Aim: CYP2C9 is one of the major drug metabolizing enzymes, however, little is known about
polymorphisms in CYP2C9 gene and pharmacological implications in Mexican indigenous …