Background The vascular endothelium represents a fundamental mechanical and biological
barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes …

Oxidative stress (OS) is an imbalance between free radicals/ROS and antioxidants, which
evokes a biological response and is an important risk factor for diseases, in both the …

The activation of the Nrf2/HO-1 signaling pathway regulates cellular antioxidant stress and
exerts anti-inflammatory and cytoprotective effects against acute lung injury (ALI). The …

Abstract NF-E2-related factor 2 (Nrf2) is a master regulator of antioxidant defense system
which can maintain the oxidation balance in the cell. In our previous study, we first cloned …

Nuclear factor erythroid 2-related factor 2 (Nrf2) promotes expression of a large number of
antioxidant genes and multiple studies have described oxidative stress and impaired …

Introduction. The present study aimed to elucidate the potential antifibrotic effects of
pinocembrin (PIN), a flavanone found abundantly in honey and propolis, by studying its …

Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for
cellular regulation against oxidative stress and inflammation, and therefore an attractive …

Among various phytochemicals, coumarins comprise a very large class of plant phenolic
compounds that have good nutritive value, in addition to their antioxidant effects. The …

Homocysteine (Hcy) and glutathione (GSH) are crucial reduction‑oxidation mediators. The
underlying mechanisms governing the effects of Hcy on GSH generation in the progression …

Abstract Background Hyperhomocysteinemia (HHcy) is an independent risk factor for liver
diseases, such as fatty liver and hepatic fibrosis. However, the mechanisms underlying this …