Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany

N Albinger, J Hartmann, E Ullrich - Gene therapy, 2021 - nature.com
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful
immunotherapeutic tools for combating hematological diseases confronted with pressing …

Engineered T cells: the promise and challenges of cancer immunotherapy

AD Fesnak, CH June, BL Levine - Nature reviews cancer, 2016 - nature.com
The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma

M Hamadani, J Radford, C Carlo-Stella… - Blood, The Journal …, 2021 - ashpublications.org
The prognosis for patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-
NHL) remains poor, with a need for alternatives to current salvage therapies. Loncastuximab …

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia

SL Maude, DT Teachey, DL Porter… - Blood, The Journal of …, 2015 - ashpublications.org
Relapsed and refractory acute lymphoblastic leukemia (ALL) remains difficult to treat, with
minimal improvement in outcomes seen in more than 2 decades despite advances in upfront …

Emerging targeted therapies for HER2-positive breast cancer

MF Mercogliano, S Bruni, FL Mauro, R Schillaci - Cancers, 2023 - mdpi.com
Simple Summary HER2-positive breast cancer (BC), which accounts for~ 20% of BC, is one
of the more aggressive and has the worst overall survival rate among them. These patients …

CAR T-cell therapy for B-cell lymphomas: clinical trial results of available products

JC Chavez, C Bachmeier… - Therapeutic …, 2019 - journals.sagepub.com
Adoptive cellular immunotherapy with chimeric antigen receptor (CAR) T cell has changed
the treatment landscape of B-cell non-Hodgkin's lymphoma (NHL), especially for aggressive …

Management of immunotherapy-related toxicities, version 1.2022, NCCN clinical practice guidelines in oncology

JA Thompson, BJ Schneider, J Brahmer… - Journal of the National …, 2022 - jnccn.org
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to
provide guidance on the management of immune-related adverse events resulting from …

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

RJ Brentjens, I Rivière, JH Park… - Blood, The Journal …, 2011 - ashpublications.org
We report the findings from the first 10 patients with chemotherapy-refractory chronic
lymphocytic leukemia (CLL) or relapsed B-cell acute lymphoblastic leukemia (ALL) we have …

The state of the art of bispecific antibodies for treating human malignancies

S Wang, K Chen, Q Lei, P Ma, AQ Yuan… - EMBO molecular …, 2021 - embopress.org
Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been
extensively explored in translational and clinical studies since they were first developed in …

Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia

N Albinger, R Pfeifer, M Nitsche, S Mertlitz… - Blood cancer …, 2022 - nature.com
Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid
progenitor cells characterized by abnormal proliferation and differentiation. Although novel …