Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

Rapid and reversible manipulations of neural activity in behaving animals are transforming
our understanding of brain function. An important assumption underlying much of this work …

Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

The need to sleep grows with the duration of wakefulness and dissipates with time spent
asleep, a process called sleep homeostasis. What are the consequences of staying awake …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Artificial neurons with functions such as leaky integrate‐and‐fire (LIF) and spike output are
essential for brain‐inspired computation with high efficiency. However, previously …

Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer
collateral inputs and postsynaptic firing is associated with localized increases in synaptic …

To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

Slow oscillations have been suggested as the default emergent activity of the cortical
network. This is a low complexity state that integrates neuronal, synaptic, and connectivity …