Background: Chronic postsurgical pain can severely impair patient health and quality of life.
This systematic review update evaluated the effectiveness of systemic drugs to prevent …

Most patients who undergo surgery recover uneventfully and resume their normal daily
activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming …

Background Chronic pain can often occur after surgery, substantially impairing patients'
health and quality of life. It is caused by complex mechanisms that are not yet well …

Abstract Purpose of Review Management of acute pain following surgery using a multimodal
approach is recommended by the American Society of Anesthesiologists whenever …

BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and
pregabalin administration in the perioperative period as an adjunct to reduce acute …

Background Perioperative neuropathic pain is under‐recognized and often undertreated.
Chronic pain may develop after any routine surgery, but it can have a far greater incidence …

Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic
postsurgical pain Perioperative gabapentinoids: choice of agent, dose, timing, and effects on …

Chronic pain is the leading cause of disability in the United States. The transition from acute
to persistent pain is thought to arise from maladaptive neuroplastic mechanisms involving …

Summary We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until
December 2014 and included 133 randomised controlled trials of peri‐operative gabapentin …

Objectives Postmastectomy pain syndrome is a neuropathic pain syndrome that is known to
develop after breast surgery. Preemptive analgesia has been shown to be efficacious in …