Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still
considered to be incurable. In recent years, whole-exome sequencing studies of large …

Abstract JASPAR (http://jaspar. genereg. net) is an open-access database of curated, non-
redundant transcription factor (TF)-binding profiles stored as position frequency matrices …

UCSC Xena is a visual exploration resource for both public and private omics data,
supported through the web-based Xena Browser and multiple turn-key Xena Hubs. This …

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-
cells. Prognosis is strongly associated with molecular subgroup, although the driver …

The comprehensive identification of mutations contributing to the development of cancer is a
priority of large cancer sequencing projects. To date, most studies have scrutinized …

Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer
(PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in …

Here we report that promoter mutations in telomerase (TERT), the most common noncoding
mutations in cancer, give rise to monoallelic expression of TERT. Through deep RNA …

The contributions of coding mutations to tumorigenesis are relatively well known; however,
little is known about somatic alterations in noncoding DNA. Here we describe GECCO …

Diseases and phenotypes caused by disrupted transcription factor (TF) binding are being
identified, but progress is hampered by our limited capacity to predict such functional …

Millions of single nucleotide variants (SNVs) exist in the human genome; however, it
remains challenging to identify functional SNVs associated with diseases. We propose a …