Diabetes in China: epidemiology and genetic risk factors and their clinical utility in personalized medication

C Hu, W Jia - Diabetes, 2018 - Am Diabetes Assoc
The incidence of type 2 diabetes (T2D) has rapidly increased over recent decades, and T2D
has become a leading public health challenge in China. Compared with European …

Genetics of type 2 diabetes—pitfalls and possibilities

RB Prasad, L Groop - Genes, 2015 - mdpi.com
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Genetic markers of type 2 diabetes: Progress in genome‐wide association studies and clinical application for risk prediction: 2 型糖尿病的遗传标记: 风险预测的全 …

X Wang, G Strizich, Y Hu, T Wang… - Journal of …, 2016 - Wiley Online Library
摘要2 型糖尿病已经成为全球公共卫生的主要挑战. 迄今为止, 通过全基因组关联研究(genome‐
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study

PC Haycock, S Burgess, A Nounu, J Zheng… - JAMA …, 2017 - jamanetwork.com
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …

The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β-Cell Function and Diabetes

MJ Varney, JL Benovic, M Michel - Pharmacological reviews, 2024 - Elsevier
Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

N Grarup, CH Sandholt, T Hansen, O Pedersen - Diabetologia, 2014 - Springer
During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …

[HTML][HTML] Research progress on traditional Chinese medicine syndromes of diabetes mellitus

J Wang, Q Ma, Y Li, P Li, M Wang, T Wang… - Biomedicine & …, 2020 - Elsevier
With the improvement of people's living standard and the changes of environment, the
incidence of diabetes mellitus (DM) is on the rise day by day, while clinical treatment mainly …

Metabolically healthy and unhealthy obese–the 2013 S tock C onference report

D Samocha‐Bonet, VD Dixit, CR Kahn… - Obesity …, 2014 - Wiley Online Library
Obesity is closely associated with cardiovascular diseases and type 2 diabetes, but some
obese individuals, despite having excessive body fat, exhibit metabolic health that is …

Rare and common genetic events in type 2 diabetes: what should biologists know?

A Bonnefond, P Froguel - Cell metabolism, 2015 - cell.com
Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …