Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

The side-effects and long-term sequelae of anti-cancer chemotherapy remain a major
source of concern for both patients and clinicians despite the improved efficacy and …

Artemisia annua is currently the only commercial source of the sesquiterpene lactone
artemisinin. Since artemisinin was discovered as the active component of A. annua in early …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free
radicals. Cancer cells contain significantly more intracellular free iron than normal cells and …

Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in
cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that …

The world is experiencing a cancer epidemic and an increase in the prevalence of the
disease. Cancer remains a major killer, accounting for more than half a million deaths …

Sesquiterpene lactones are of considerable interest due to their potent bioactivities,
including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these …

As long as no effective malaria vaccine is available, chemotherapy belongs to the most
important weapons fighting malaria. One of the most promising new drug developments is …

Secondary metabolites from plants can serve as defense against herbivores, microbes,
viruses or competing plants. Many compounds from medicinal plants have pharmacological …