The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3′-
flanking sequence which can mediate a sevenfold transcriptional induction in response to …

Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …

Small-molecule stabilizers of hypoxia inducible factor (HIF) are being developed for the
treatment of renal anaemia. These molecules inhibit prolyl hydroxylase domain-containing …

Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to
hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is …

Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …

Hemopoiesis counterbalances the continuous loss of aged blood cells. Young progeny are
generated by myeloid and lymphoid progenitors that originate from a small pool of …

Cellular responses to oxygen are increasingly recognized as critical in normal development
and physiology, and are implicated in pathological processes. Many of these responses are …

Erythropoietin(EPO) is the principal growth factor regulating the production of circulating
erythrocytes. We introduced null mutations into both Epo and the EPO receptor (EpoR) …