Inositol derivatives: evolution and functions

RH Michell - Nature reviews Molecular cell biology, 2008 - nature.com
Current research on inositols mainly focuses on myo-inositol (Ins) derivatives in eukaryotic
cells, and in particular on the many roles of Ins phospholipids and polyphosphorylated Ins …

DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals

X Chen, C Gao, L Guo, G Hu, Q Luo, J Liu… - Chemical …, 2018 - ACS Publications
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

[HTML][HTML] Microbial production of extremolytes—high-value active ingredients for nutrition, health care, and well-being

J Becker, C Wittmann - Current opinion in biotechnology, 2020 - Elsevier
Highlights•Extremolytes protect extremophilic microbes from environmental stress.•They
enable multiple applications in cosmetics, food, and health industry.•Ectoine is the industrial …

Structural basis for catalysis in a CDP-alcohol phosphotransferase

G Sciara, OB Clarke, D Tomasek, B Kloss… - Nature …, 2014 - nature.com
The CDP-alcohol phosphotransferase (CDP-AP) family of integral membrane enzymes
catalyses the transfer of a substituted phosphate group from a CDP-linked donor to an …

Inositol and its derivatives: their evolution and functions

RH Michell - Advances in enzyme regulation, 2011 - Elsevier
The last quarter of century has seen an extraordinarily diverse set of functions assigned to
inositol (Ins) phospholipids and inositol polyphosphates. Most of the key advances have …

X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism

P Nogly, I Gushchin, A Remeeva, AM Esteves… - Nature …, 2014 - nature.com
Phospholipids have major roles in the structure and function of all cell membranes. Most
integral membrane proteins from the large CDP-alcohol phosphatidyltransferase family are …

Thermococcus kodakarensis Mutants Deficient in Di-myo-Inositol Phosphate Use Aspartate To Cope with Heat Stress

N Borges, R Matsumi, T Imanaka, H Atomi… - Journal of …, 2010 - Am Soc Microbiol
Many of the marine microorganisms which are adapted to grow at temperatures above 80° C
accumulate di-myo-inositol phosphate (DIP) in response to heat stress. This led to the …

Bifunctional CTP:Inositol-1-Phosphate Cytidylyltransferase/CDP-Inositol:Inositol-1-Phosphate Transferase, the Key Enzyme for Di-myo-Inositol-Phosphate Synthesis …

MV Rodrigues, N Borges, M Henriques… - Journal of …, 2007 - Am Soc Microbiol
The pathway for the synthesis of di-myo-inositol-phosphate (DIP) was recently elucidated on
the basis of the detection of the relevant activities in cell extracts of Archaeoglobus fulgidus …

Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate

DA Rodionov, OV Kurnasov, B Stec… - Proceedings of the …, 2007 - National Acad Sciences
Di-myo-inositol 1, 1′-phosphate (DIP) is a major osmoprotecting metabolite in a number of
hyperthermophilic species of archaea and bacteria. Although the DIP biosynthesis pathway …

Evolution of the biosynthesis of di‐myo‐inositol phosphate, a marker of adaptation to hot marine environments

LG Gonçalves, N Borges, F Serra… - Environmental …, 2012 - Wiley Online Library
The synthesis of di‐myo‐inositol phosphate (DIP), a common compatible solute in
hyperthermophiles, involves the consecutive actions of inositol‐1‐phosphate …