Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

Globoid cell leukodystrophy (GLD; Krabbe disease) is a progressive, incurable
neurodegenerative disease caused by deficient activity of the hydrolytic enzyme …

Krabbe disease (globoid cell leukodystrophy) is a lysosomal storage disease (LSD)
characterized by progressive and profound demyelination. Infantile, juvenile and adult-onset …

Rare genetic diseases affect a limited number of patients, but their etiology is often known,
facilitating the development of reliable animal models and giving the opportunity to …

Krabbe disease (KD) is a lysosomal storage disease (LSD) caused by mutations in the galc
gene. There are over 50 monogenetic LSDs, which largely impede the normal development …

With the rapid aging in the global population, delay of aging has become a hot research
topic. Lipid rafts (LRs) are microdomains in the plasma membrane that contain sphingolipids …

Neuronal polarization and growth are developmental processes that occur during neuronal
cell differentiation. The molecular signaling mechanisms involved in these events in in vivo …

Lysosomal storage diseases are a group of rare and ultra-rare genetic disorders caused by
defects in specific genes that result in the accumulation of toxic substances in the lysosome …

Malignant brain aging corresponds to accelerated age-related declines in brain functions
eventually derailing the self-sustaining forces that govern independent vitality. Malignant …