Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

The gut microbiota plays a crucial role in the conversion of dietary flavonoids and thereby
affects their health-promoting effects in the human host. The identification of the bacteria …

Recent studies of multiple enzyme families collectively called ene-reductases (ERs) have
highlighted potential industrial applications of these biocatalysts in the production of fine and …

Nature's smartness and efficient assembling cascade type reactions inspired biologists and
chemists all around the world. Tremendous effort has been directed towards the …

Gut microbiota contribute to the metabolism of dietary polyphenols and affect the
bioavailability of both the parent polyphenols and their metabolites. Although there is a large …

Natural products have been extensively applied in clinical practice, characterized by multi-
component and multi-target, many pharmacodynamic substances, complex action …

Highlights•Metabolic engineering enables the microbial production of many compounds.•
Advances in engineering of yeast for production of valuable isoprenoids and aromatics are …

Gut microbial transformations of flavonoids, an enormous class of polyphenolic compounds
abundant in plant-based diets, are closely associated with human health. However, the …

Female hop cones are used extensively in the brewing industry, but there is now increasing
interest in possible uses of hops for non-brewing purposes, especially in the pharmaceutical …

Flavonoids are important plant natural products with variable structures and bioactivities. All
known plant flavonoids are generated under the catalysis of a type III polyketide synthase …