Simple Summary The ATPase Inhibitory Factor 1 (IF1) plays a prominent role as an inhibitor
of mitochondrial ATP synthase. Herein we review the role of IF1 in promoting the Warburg …

Mammalian F-ATP synthase is central to mitochondrial bioenergetics and is present in the
inner mitochondrial membrane in a dynamic oligomeric state of higher oligomers, tetramers …

Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy
metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a …

ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP
synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is …

T cells experience metabolic reprogramming to an enhanced glycolysis upon activation.
Herein, we have investigated whether ATPase Inhibitory Factor 1 (IF1), the physiological …

The production of energy in the form of ATP by the mitochondrial ATP synthase must be
tightly controlled. One well-conserved form of regulation is mediated via ATPase inhibitory …

Despite early optimism, therapeutics targeting oxidative phosphorylation (OxPhos) have
faced clinical setbacks, stemming from their inability to distinguish healthy from cancerous …

Ischemic conditions can flip the action of mitochondrial ATP-synthase from an ATP
producing to an ATP consuming enzyme. The mitochondrial protein ATPase inhibitory factor …