Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Recent studies have identified a specialized subset of CD31hiendomucinhi
(CD31hiEMCNhi) vascular endothelium that positively regulates bone formation. However, it …

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Bone formation in mammals requires continuous production of osteoblasts throughout life. A
common molecular marker for all osteogenic mesenchymal progenitors has not been …

YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo
pathway, a conserved pathway for the development and size control of multiple organs. The …

The hallmark of endochondral bone development is the presence of cartilaginous templates,
in which osteoblasts and stromal cells are generated to form mineralized matrix and support …

Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …