Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis

J Meyer, LE Meyer, S Kara - Engineering in Life Sciences, 2022 - Wiley Online Library
Biocatalysis is an established chemical synthesis technology that has by no means been
restricted to research laboratories. The use of enzymes for organic synthesis has evolved …

Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects

M Zhou, OA Fakayode, M Ren, H Li, J Liang… - Bioresources and …, 2023 - Springer
Lignin has enormous potential as a renewable feedstock for depolymerizing to numerous
high-value chemicals. However, lignin depolymerization is challenging owing to its …

Impact of deep eutectic solvents (DESs) and individual DES components on alcohol dehydrogenase catalysis: connecting experimental data and molecular dynamics …

JP Bittner, N Zhang, L Huang, PD de María… - Green chemistry, 2022 - pubs.rsc.org
For a knowledge-based design of enzyme catalysis in deep eutectic solvents (DESs), the
influence of the DES properties (eg, water activity and viscosity) and the impact of DESs and …

Radical-mediated thiol–ene 'click'reactions in deep eutectic solvents for bioconjugation

MD Nolan, A Mezzetta, L Guazzelli, EM Scanlan - Green Chemistry, 2022 - pubs.rsc.org
Herein, we report the first application of deep eutectic solvents (DESs) in radical-mediated
hydrothiolation reactions. Under UV and atmospheric-oxygen mediated conditions, the thiol …

Deep eutectic solvents for the enzymatic synthesis of sugar esters: a generalizable strategy?

R Semproli, SN Chanquia, JP Bittner… - ACS sustainable …, 2023 - ACS Publications
Sugar (fatty acid) esters are industrially relevant compounds, with a cumbersome production
process due to the solubility issues of the substrates, which forces the use of …

A deep eutectic solvent thermomorphic multiphasic system for biocatalytic applications

LE Meyer, MB Andersen, S Kara - … Chemie International Edition, 2022 - Wiley Online Library
The applicability of a thermomorphic multiphasic system (TMS) composed of a hydrophobic
deep eutectic solvent (DES) and an aqueous potassium phosphate buffer with a lower …

Green and sustainable solvents for biocatalytic oxidations

RA Sheldon, ML Bode, N Mathebula - Current Opinion in Green and …, 2023 - Elsevier
The discovery that enzymes could function efficiently in organic solvents revolutionized their
use in industry but represented a change from the natural “green” solvent, water, to a host of …

Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

N Zhang, P Domínguez de María, S Kara - Catalysts, 2024 - mdpi.com
Biocatalysis holds immense potential for pharmaceutical development as it enables
synthetic routes to various chiral building blocks with unparalleled selectivity. Therein …

[HTML][HTML] Process intensification in oxidative biocatalysis

G Vernet, M Hobisch, S Kara - Current Opinion in Green and Sustainable …, 2022 - Elsevier
In the last ten years, the number of publications related to process intensification (PI) has
been quadrupled. This increasing interest that created many innovations can be found not …

Selective Aerobic Oxidation of Alcohols in Low Melting Mixtures and Water and Use for Telescoped One‐Pot Hybrid Reactions

L Cicco, M Roggio, M López‐Aguilar… - …, 2022 - Wiley Online Library
An efficient, selective and sustainable protocol was developed for the CuCl2/TEMPO/
TMEDA‐catalyzed aerobic oxidation of activated alcohols to the corresponding carbonyl …