Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality
but lacks specific therapeutic options. Diverse endocytic processes play a key role in all …

Abstract The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to
drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 …

Cross-talk between Rho-and Arf-family guanosine triphosphatases (GTPases) plays an
important role in linking the actin cytoskeleton to membrane protrusions, organelle …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

Cells are subjected to a barrage of daily insults that often lead to their cortices being ripped
open and requiring immediate repair. An important component of the cell's repair response …

The axon guidance cue netrin-1 signals through its receptor DCC (deleted in colorectal
cancer) to attract commissural axons to the midline. Variants in DCC are frequently …

To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae
secretes early effector proteins, which bind to and modulate the host-cell's plasma …

The actin cytoskeleton is a ubiquitous participant in cellular functions that maintain viability,
but how it controls programmed cell death is not well understood. Here we show that in …

The actin cytoskeleton is essential for many functions of eukaryotic cells, but the factors that
nucleate actin assembly are not well understood at the organismal level or in the context of …