Angiotensin-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase and
is crucial in the renin-angiotensin-aldosterone system (RAAS) but also implicated in immune …

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder,
characterized by the deposition of amyloid-β within the brain parenchyma resulting in a …

Accumulating evidence has indicated the implication of angiotensin II in the pathogenesis of
inflammatory bowel diseases (IBD) via its proinflammatory features. Telmisartan (TLM) is an …

Abstract Angiotensin-converting enzyme-2 (ACE-2) is a homolog of ACE that preferentially
forms angiotensin-(ANG)-1-7 from angiotensin II (ANG II). We investigated the …

Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and
adolescents. Many cases of myocarditis are associated with autoimmune processes in …

The renin-angiotensin (Ang) system (RAS) is a complex hormonal system present locally in
several tissues such as cardiovascular organs. RAS deregulation through overactivation of …

We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

Increasing evidence suggests male sex as a potential risk factor for a higher incidence of
cardiac fibrosis, stronger cardiac inflammation, and dilated cardiomyopathy (DCM) in human …

Heart failure (HF) occurs when the adaptation mechanisms of the heart fail to compensate
for stress factors, such as pressure overload, myocardial infarction, inflammation, diabetes …

Abstract Aims Angiotensin (Ang) II signalling has been suggested to promote cardiac fibrosis
in inflammatory heart diseases; however, the underlying mechanisms remain obscure …