The GCN5: its biological functions and therapeutic potentials

ME Haque, M Jakaria, M Akther, DY Cho… - Clinical …, 2021 - portlandpress.com
General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …

Complex functions of Gcn5 and Pcaf in development and disease

E Koutelou, AT Farria, SYR Dent - Biochimica et Biophysica Acta (BBA) …, 2021 - Elsevier
A wealth of biochemical and cellular data, accumulated over several years by multiple
groups, has provided a great degree of insight into the molecular mechanisms of actions of …

Acetylation-dependent SAGA complex dimerization promotes nucleosome acetylation and gene transcription

J Huang, W Dai, D Xiao, Q Xiong, C Liu, J Hu… - Nature Structural & …, 2022 - nature.com
Cells reprogram their transcriptomes to adapt to external conditions. The SAGA (Spt-Ada-
Gcn5 acetyltransferase) complex is a highly conserved transcriptional coactivator that plays …

Histone deacetylase AtSRT2 regulates salt tolerance during seed germination via repression of vesicle‐associated membrane protein 714 (VAMP714) in Arabidopsis

W Tang, L Zhong, Q Ding, Y Dou, W Li, Z Xu… - New …, 2022 - Wiley Online Library
Salt tolerance during seed germination is essential for seedling establishment under salt
stress. Sirtuin‐like proteins, NAD+‐dependent histone deacetylases, are involved in plant …

ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C Yin, C Zhang, Y Wang, G Liu, N Wang, N Liang… - Hepatology, 2025 - journals.lww.com
Abstract Background and Aims: Cross talk between tumor cells and immune cells enables
tumor cells to escape immune surveillance and dictate responses to immunotherapy …

The Response of Rhodotorula mucilaginosa to Patulin Based on Lysine Crotonylation

Q Yang, Y Li, MT Apaliya, X Zheng… - Frontiers in …, 2018 - frontiersin.org
Patulin (PAT) is a mycotoxin produced by some Penicillium, Aspergillus, and Byssochlamys
species. Rhodotorula mucilaginosa is able to degrade PAT in vivo as well as in vitro, up till …

Unraveling the molecular mechanism of FgGcn5 inhibition by phenazine‐1‐carboxamide: combined in silico and in vitro studies

L Li, Q Luo, S Yang, H Wang, Y Mu… - Pest Management …, 2025 - Wiley Online Library
BACKGROUND Fusarium head blight (FHB), mainly caused by Fusarium graminearum (F.
graminearum), remains a devastating disease worldwide. The histone acetyltransferase …

Epidermal growth factor receptor activation promotes ADA3 acetylation through the AKT-p300 pathway

S Srivastava, S Mohibi, S Mirza, H Band, V Band - Cell Cycle, 2017 - Taylor & Francis
ABSTRACT The ADA3 (Alteration/Deficiency in Activation 3) protein is an essential adaptor
component of several L ysine A cetyl t ransferase (KAT) complexes involved in chromatin …

Cucurbitacin I exerts its anticancer effects by inducing cell cycle arrest via the KAT2a-ube2C/E2F1 pathway and inhibiting HepG2-induced macrophage M2 …

X Gong, Y Liu, K Liang, Z Chen, K Ding, L Qiu… - Biochemical and …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignancies globally,
particularly prevalent in China, where it accounts for nearly half of the world's new cases and …

Deacetylation of BmAda3 is required for cell apoptosis caused by Bombyx mori nucleopolyhedrovirus infection

Y Zhu, M Hu, J Ngowo, X Gao, X Chen… - Archives of Insect …, 2021 - Wiley Online Library
Silkworm is not only an ideal insect model with a biological significance, but it is also
crucially important in sericulture and bioreactors. Bombyx mori nucleopolyhedrovirus …