Over the last decade, the zebrafish has entered the field of cardiovascular research as a
new model organism. This is largely due to a number of highly successful small-and large …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

Rationale: The developing heart requires both mechanical load and vascularization to reach
its proper size, yet the regulation of human heart growth by these processes is poorly …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …

Branching morphogenesis is the developmental program that builds the ramified epithelial
trees of various organs, including the airways of the lung, the collecting ducts of the kidney …

Discusses research which examined how a mechanical strain of embryonic stem (ES) cells
initiates the cardiovascular differentiation program. Analysis of the role of nicotinamide …

The past decade or so has seen rapid progress in our understanding of how left-right (LR)
asymmetry is generated in vertebrate embryos. However, many important questions about …

Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The …