BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Abstract gadd153, also known as chop, is a highly stress-inducible gene that is robustly
expressed following disruption of homeostasis in the endoplasmic reticulum (ER)(so-called …

Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …

Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …

An increasing body of evidence from animal models, human specimens and cell lines points
to reactive oxygen species as likely involved in the pathways, which convey both …

Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from
antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol of …

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and
rate-limiting step in GSH synthesis is catalyzed by glutamate cysteine ligase (GCL …

The mechanisms of thiol metabolism and chemistry have particular relevance to both
cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on …