Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

DJ Tyrrell, DR Goldstein - Nature Reviews Cardiology, 2021 - nature.com
The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

[HTML][HTML] The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

DJ Wilkinson, M Piasecki, PJ Atherton - Ageing research reviews, 2018 - Elsevier
Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with
physical frailty and increased risk of morbidity (chronic diseases), in addition to all-cause …

Strategies to prevent sarcopenia in the aging process: role of protein intake and exercise

PS Rogeri, R Zanella Jr, GL Martins, MDA Garcia… - Nutrients, 2021 - mdpi.com
Sarcopenia is one of the main issues associated with the process of aging. Characterized by
muscle mass loss, it is triggered by several conditions, including sedentary habits and …

[HTML][HTML] Clinical definition of sarcopenia

V Santilli, A Bernetti, M Mangone… - Clinical cases in mineral …, 2014 - ncbi.nlm.nih.gov
Sarcopenia is a condition characterized by loss of skeletal muscle mass and function.
Although it is primarily a disease of the elderly, its development may be associated with …

Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis

GJ Grosicki, RA Fielding, MS Lustgarten - Calcified tissue international, 2018 - Springer
Skeletal muscle is a highly plastic tissue that plays a central role in human health and
disease. Aging is associated with a decrease in muscle mass and function (sarcopenia) that …

Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty

MB Stout, JN Justice, BJ Nicklas, JL Kirkland - Physiology, 2017 - journals.physiology.org
Advancing age is associated with progressive declines in physiological function that lead to
overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological …

Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on …

RA Fielding, B Vellas, WJ Evans, S Bhasin… - Journal of the American …, 2011 - Elsevier
Sarcopenia, the age-associated loss of skeletal muscle mass and function, has considerable
societal consequences for the development of frailty, disability, and health care planning. A …

Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity

SG Wannamethee, JL Atkins - Proceedings of the Nutrition Society, 2015 - cambridge.org
This paper reviews the health implications of obesity, sarcopenia and sarcopenic obesity on
CVD and mortality in older adults and discusses the obesity paradox seen in patients with …