Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …

Mass spectrometry (MS) based techniques are gaining popularity for metabolomics research
due to their high sensitivity, wide detection range, and capability of molecular identification …

Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …

Metabolite-protein interactions control a variety of cellular processes, thereby playing a
major role in maintaining cellular homeostasis. Metabolites comprise the largest fraction of …

By the time the complete genome sequence of the soil bacterium Pseudomonas putida
KT2440 was published in 2002 (Nelson et al.,) this bacterium was considered a potential …

The costs and benefits of protein expression are balanced through evolution. Expression of
un-utilized protein (that have no benefits in the current environment) incurs a quantifiable …

Transcriptional regulatory networks (TRNs) have been studied intensely for> 25 y. Yet, even
for the Escherichia coli TRN—probably the best characterized TRN—several questions …

Animal biotechnology is a broad field including polarities of fundamental and applied
research, as well as DNA science, covering key topics of DNA studies and its recent …

Maintenance of a properly folded proteome is critical for bacterial survival at notably different
growth temperatures. Understanding the molecular basis of thermoadaptation has …

Phototrophic organisms exhibit a highly dynamic proteome, adapting their biomass
composition in response to diurnal light/dark cycles and nutrient availability. Here, we used …