Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Hemodynamic actions of insulin depend largely on the hormone's ability to stimulate
synthesis and release of endothelial mediators, whose balanced activity ensures dynamic …

One of the most profound challenges facing public health and public health policy in
Western society is the increased incidence and prevalence of both overweight and obesity …

Background and Purpose Obesity is associated with structural and functional changes in
perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS) …

Introduction The combination of the independent risk factors for erectile dysfunction, obesity,
hypertension, and diabetes are manifested collectively in a condition known as metabolic …

Insulin resistance plays a key role in the pathogenesis of type 2 diabetes and is also related
to other health problems like obesity, hypertension, and metabolic syndrome. Imbalance …

Individuals with metabolic syndrome exhibit insulin resistance and an attenuated functional
vasodilatory response to exercise. We have shown that impaired functional vasodilation in …

Approximately 40% of patients with type 2 diabetes present with concurrent hypertension at
the time of diabetes diagnosis. Increases in peripheral vascular resistance and …

The increased prevalence of obesity in Western society has been well established for many
years, and with this trend, the prevalence of other associated pathologies including insulin …

To determine the impact of progressive elevations in peripheral vascular disease (PVD) risk
on microvascular function, we utilized eight rat models spanning “healthy” to “high PVD risk” …