Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

Background Indirubin is the main bioactive component of the traditional Chinese medicine
Indigo naturalis and is a bisindole alkaloid. Multiple studies have shown that indirubin …

Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological
lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological …

Pharmacological inhibitors of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent
kinases have a promising potential for applications against several neurodegenerative …

Isatin (1H-indole-2, 3-dione) and its derivatives demonstrate a diverse array of biological
and pharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral …

Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Stat3 protein has an important role in oncogenesis and is a promising anticancer target.
Indirubin, the active component of a traditional Chinese herbal medicine, has been shown …

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …