Developmental programming in response to maternal overnutrition

MZ Alfaradhi, SE Ozanne - Frontiers in genetics, 2011 - frontiersin.org
Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models

M Li, DM Sloboda, MH Vickers - Journal of Diabetes Research, 2011 - Wiley Online Library
The incidence of obesity and overweight has reached epidemic proportions in the
developed world as well as in those countries transitioning to first world economies, and this …

The early origins of obesity and insulin resistance: timing, programming and mechanisms

LM Nicholas, JL Morrison, L Rattanatray… - International journal of …, 2016 - nature.com
Maternal obesity is associated with an increased risk of developing gestational diabetes
mellitus and it also results in an increased risk of giving birth to a large baby with increased …

Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk

W Gohir, EM Ratcliffe, DM Sloboda - Pediatric research, 2015 - nature.com
Chronic disease risk is inextricably linked to our early-life environment, where maternal,
fetal, and childhood factors predict disease risk later in life. Currently, maternal obesity is a …

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth

FJ Rosario, Y Kanai, TL Powell, T Jansson - Obesity, 2015 - Wiley Online Library
Objective To identify possible mechanisms linking obesity in pregnancy to increased fetal
adiposity and growth, a unique mouse model of maternal obesity associated with fetal …

Diet before and during pregnancy and offspring health: the importance of animal models and what can be learned from them

P Chavatte-Palmer, A Tarrade… - International journal of …, 2016 - mdpi.com
This review article outlines epidemiologic studies that support the hypothesis that maternal
environment (including early nutrition) plays a seminal role in determining the offspring's …

Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia

A Hufnagel, L Dearden… - Journal of …, 2022 - joe.bioscientifica.com
Obesity and gestational diabetes during pregnancy have multiple short-and long-term
consequences for both mother and child. One common feature of pregnancies complicated …

Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring

S Kislal, LL Shook, AG Edlow - Prenatal diagnosis, 2020 - Wiley Online Library
Evidence from epidemiological, clinical, and animal model studies clearly demonstrates that
prenatal and lactational maternal obesity and high‐fat diet consumption are associated with …

The placenta is the center of the chronic disease universe

KL Thornburg, N Marshall - American Journal of Obstetrics & Gynecology, 2015 - ajog.org
Over the past quarter century, the scientific community has gained a new perspective on the
origins of chronic disease, which now includes a central role for the placenta. It began when …

Impact of fetal and neonatal environment on beta cell function and development of diabetes

JH Nielsen, TN Haase, C Jaksch… - Acta obstetricia et …, 2014 - Wiley Online Library
The global epidemic of diabetes is a serious threat against health and healthcare expenses.
Although genetics is important it does not explain the dramatic increase in incidence, which …