The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …

One of the most salient features of Bacillus subtilis and related bacilli is their natural capacity
to secrete a variety of proteins into their environment, frequently to high concentrations. This …

Leigh Syndrome (LS) is a severe neurological disorder characterized by bilaterally
symmetrical necrotic lesions in subcortical brain regions that is commonly associated with …

Mammalian cytochrome c oxidase (COX) catalyses the transfer of reducing equivalents from
cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial …

The ribosome is a structurally and functionally conserved macromolecular machine
universally responsible for catalyzing protein synthesis. Within eukaryotic cells, mitochondria …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial
respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin …

Protein synthesis in mammalian mitochondria produces 13 proteins that are essential
subunits of the oxidative phosphorylation complexes. This review provides a detailed outline …

Mitochondrial dysfunction has been implicated in a variety of human disorders—the so-
called mitochondrial diseases. Therefore, the organelle is a promising therapeutic drug …

Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria
by protein translocases. Yet, mitochondria contain their own genome and gene expression …