Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …
disease. The regulatory relationship between transcription factors (TFs), key regulators of …
Integrated intra‐and intercellular signaling knowledge for multicellular omics analysis
D Türei, A Valdeolivas, L Gul… - Molecular systems …, 2021 - embopress.org
Molecular knowledge of biological processes is a cornerstone in omics data analysis.
Applied to single‐cell data, such analyses provide mechanistic insights into individual cells …
Applied to single‐cell data, such analyses provide mechanistic insights into individual cells …
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological …
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
[HTML][HTML] Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
NB Leimkühler, HFE Gleitz, L Ronghui, IAM Snoeren… - Cell stem cell, 2021 - cell.com
Functional contributions of individual cellular components of the bone-marrow
microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms …
microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms …
Resources and tools for rare disease variant interpretation
Collectively, rare genetic disorders affect a substantial portion of the world's population. In
most cases, those affected face difficulties in receiving a clinical diagnosis and genetic …
most cases, those affected face difficulties in receiving a clinical diagnosis and genetic …
Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma
SUMMARY Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (hereafter, GB), is an
aggressive brain malignancy associated with a dismal prognosis and poor quality of life …
aggressive brain malignancy associated with a dismal prognosis and poor quality of life …
Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus
S Li, W Liu, Y Chen, L Wang, W An, X An… - Briefings in …, 2021 - academic.oup.com
Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are
urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a …
urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a …
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney
MM Rinschen, JL Harder, ME Carter-Timofte… - Science …, 2022 - science.org
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is
implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key …
implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key …
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2
diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role …
diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role …