Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

Developing effective drugs for Alzheimer's disease (AD), the most common cause of
dementia, has been difficult because of complicated pathogenesis. Here, we report an …

Growing evidence suggests that synaptic signaling is compromised in the aging brain and in
Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent …

The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …

Saliva is a body fluid with important functions in oral and general health. A consortium of
three research groups catalogued the proteins in human saliva collected as the ductal …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …

Tau is a neuronal microtubule-associated phosphoprotein that is highly phosphorylated by
glycogen synthase kinase 3 (GSK3). Tau phosphorylation by GSK3 regulates tau binding to …