Obstructive sleep apnea and the metabolic syndrome: the road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment

J Gaines, AN Vgontzas, J Fernandez-Mendoza… - Sleep medicine …, 2018 - Elsevier
Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by
upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia …

Serum inflammatory markers in obstructive sleep apnea: a meta-analysis

R Nadeem, J Molnar, EM Madbouly, M Nida… - Journal of Clinical …, 2013 - jcsm.aasm.org
Study Objectives: Obstructive sleep apnea (OSA) has been linked to and is associated with
increased cardiovascular and cerebrovascular morbidity. Ongoing inflammatory responses …

Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea

LH White, TD Bradley - The Journal of physiology, 2013 - Wiley Online Library
Obstructive sleep apnoea (OSA) is common in the general population and increases the risk
of motor vehicle accidents due to hypersomnolence from sleep disruption, and risk of …

Pathophysiology of upper airway obstruction: a developmental perspective

R Arens, CL Marcus - Sleep, 2004 - academic.oup.com
The obstructive sleep apnea syndrome (OSAS) occurs in patients of all ages, from the
premature infant to the elderly. Much remains unknown about the pathophysiology of the …

Physical findings and the risk for obstructive sleep apnea: the importance of oropharyngeal structures

JB Schellenberg, G Maislin… - American journal of …, 2000 - atsjournals.org
In this study, we hypothesized that anatomic abnormalities of the oropharynx, particularly
narrowing of the airway by the lateral pharyngeal walls, tonsils, and tongue, would be …

Magnetic resonance imaging of the upper airway structure of children with obstructive sleep apnea syndrome

R Arens, JM McDONOUGH, AT Costarino… - American journal of …, 2001 - atsjournals.org
The anatomical relationships between lymphoid, bony, and other tissues affecting the shape
of the upper airway in children with obstructive sleep apnea syndrome (OSAS) have not …

Upper airway muscle inflammation and denervation changes in obstructive sleep apnea

JH Boyd, BJ Petrof, Q Hamid, R Fraser… - American journal of …, 2004 - atsjournals.org
Inflammatory cell infiltration and afferent neuropathy have been shown in the upper airway
(UA) mucosa of subjects with obstructive sleep apnea (OSA). We hypothesized that …

Leukotriene modifier therapy for mild sleep-disordered breathing in children

AD Goldbart, JL Goldman, MC Veling… - American journal of …, 2005 - atsjournals.org
Background: Children with mild sleep-disordered breathing (SDB), who may not be
recommended for adenotonsillectomy, frequently exhibit neurocognitive and behavioral …

Gender differences in the expression of sleep-disordered breathing: role of upper airway dimensions

V Mohsenin - Chest, 2001 - Elsevier
Study objectives Obstructive sleep apnea (OSA) is a common disorder that is characterized
by repetitive episodes of upper airway narrowing and collapse. Obesity is a major risk factor …

Intranasal steroids and oral leukotriene modifier therapy in residual sleep-disordered breathing after tonsillectomy and adenoidectomy in children

L Kheirandish, AD Goldbart, D Gozal - Pediatrics, 2006 - publications.aap.org
OBJECTIVE. Tonsillectomy and adenoidectomy (T&A) is the primary therapeutic approach
for sleep-disordered breathing (SDB) in children. However, residual mild SDB will be found …