Technological advances in imaging techniques and biometric data acquisition have enabled
us to apply methods of network science to study the morphology and structural design of …

Endovascular therapy is the first-line treatment for acute ischemic stroke. However, studies
have shown that, even with the timely opening of occluded blood vessels, nearly half of all …

Cerebral perfusion modelling is a promising tool to predict the impact of acute ischaemic
stroke treatments on the spatial distribution of cerebral blood flow (CBF) in the human brain …

An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual
patients to support the development and evaluation of medical devices, drugs, and …

Computational physiological models are promising tools to enhance the design of clinical
trials and to assist in decision making. Organ-scale haemodynamic models are gaining …

The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite
the close coupling between cerebral vascular geometry and local oxygen demand, recent …

Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …

Thrombectomy, the mechanical removal of a clot, is the most common way to treat ischaemic
stroke with large vessel occlusions. However, perfusion cannot always be restored after …

Animal testing is often criticized due to ethical issues and complicated translation of the
results obtained to the clinical stage of drug development. Existing alternative models for …

The glymphatic system is the subject of numerous pieces of research in biology.
Mathematical modelling plays a considerable role in this field since it can indicate the …