Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease

D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …

Avidity in antibody effector functions and biotherapeutic drug design

SC Oostindie, GA Lazar, J Schuurman… - Nature Reviews Drug …, 2022 - nature.com
Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

The role of IgG Fc receptors in antibody-dependent enhancement

S Bournazos, A Gupta, JV Ravetch - Nature Reviews Immunology, 2020 - nature.com
Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of
certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non …

[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A Schäfer, F Muecksch, JCC Lorenzi, SR Leist… - Journal of Experimental …, 2020 - rupress.org
SARS-CoV-2, the causative agent of COVID-19, has been responsible for over 42 million
infections and 1 million deaths since its emergence in December 2019. There are few …

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
Monoclonal antibodies with neutralizing activity against SARS-CoV-2 have demonstrated
clinical benefits in cases of mild-to-moderate SARS-CoV-2 infection, substantially reducing …

Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

YC Bartsch, X Tong, J Kang, MJ Avendaño… - Science translational …, 2022 - science.org
The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies
elicited by vaccination or infection. Despite the global spread of the Omicron variant, even …

Beyond binding: antibody effector functions in infectious diseases

LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …