Role of cytochrome P450 2C8 in drug metabolism and interactions
Abstract During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies
An assessment of cytochrome P450 (CYP) enzyme activity is essential for characterizing the
phase I metabolism of biological systems or to evaluate the inhibition/induction properties of …
phase I metabolism of biological systems or to evaluate the inhibition/induction properties of …
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
Major depressive disorder is associated with abnormalities in the brain and the immune
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms …
Bis-(Imidazole/Benzimidazole)-Pyridine Derivatives: Synthesis, Structure and Antimycobacterial Activity
V Antoci, D Cucu, G Zbancioc… - Future Medicinal …, 2020 - Taylor & Francis
Aim: Over the last decades, few significant achievements have been made in tuberculosis
(TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new …
(TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new …
High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry
J Wu, CS Hughes, P Picard, S Letarte… - Analytical …, 2007 - ACS Publications
This paper describes the development of a high-throughput method for the analysis of
cytochrome P450 (CYP) inhibition assay incubation samples using laser diode thermal …
cytochrome P450 (CYP) inhibition assay incubation samples using laser diode thermal …
Direct and metabolism‐dependent cytochrome P450 inhibition assays for evaluating drug–drug interactions
KS Lee, SK Kim - Journal of Applied Toxicology, 2013 - Wiley Online Library
We developed methods for evaluating the ntial inhibition of human cytochrome P450 (CYP)
enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2 C9, CYP2 C19, CYP2D6, CYP2E1 …
enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2 C9, CYP2 C19, CYP2D6, CYP2E1 …
Evaluation of metabolism-mediated herb-drug interactions
DH Na, HY Ji, EJ Park, MS Kim, KH Liu… - Archives of pharmacal …, 2011 - Springer
As the use of herbal medicines increases, the public health consequences of drug-herb
interactions are becoming more significant. Herbal medicines share the same drug …
interactions are becoming more significant. Herbal medicines share the same drug …
Novel small-molecule inhibitor of NLRP3 inflammasome reverses cognitive impairment in an Alzheimer's disease model
Aberrant activation of the Nod-like receptor family pyrin domain-containing 3 (NLRP3)
inflammasome plays an essential role in multiple diseases, including Alzheimer's disease …
inflammasome plays an essential role in multiple diseases, including Alzheimer's disease …
Coupling IR-MALDESI with drift tube ion mobility-mass spectrometry for high-throughput screening and imaging applications
M Ekelöf, J Dodds, S Khodjaniyazova… - Journal of the …, 2020 - ACS Publications
Because of its high degree of selectivity and chemical resolution, mass spectrometry (MS) is
rapidly becoming the analytical method of choice for high-throughput evaluations and …
rapidly becoming the analytical method of choice for high-throughput evaluations and …