Immunotherapeutic approaches for the treatment of Parkinson's disease (PD) and related
synucleinopathies have steadily developed over the last two decades with several iterations …

Beta-glucocerebrosidase is a lysosomal hydrolase, encoded by GBA1 that represents the
most common risk gene associated with Parkinson's disease (PD) and Lewy Body …

In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory
system and the dorsal motor nucleus of the vagus nerve before spreading to connected …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and
motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor …

Animal models of Parkinson's disease (PD) are essential to investigate pathogenic
pathways at the whole-organism level. Moreover, they are necessary for a preclinical …

The development of high efficiency, central nervous system (CNS) targeting AAV-based
gene therapies is necessary to address challenges in both pre-clinical and clinical …

The degeneration of dopaminergic and other neurons in the aging brain is considered a
process starting well beyond the infantile and juvenile period. In contrast to other dopamine …

Abnormal accumulation of insoluble α-synuclein (α-Syn) inclusions in neurons, neurites, and
glial cells is the defining neuropathology of synucleinopathies, including Parkinson's …

In this study, we develop and validate a new Parkinson's disease (PD) mouse model that
can be used to better understand how the disease progresses and to test the effects of new …

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
repetitive behaviors, poor social skills, and difficulties with communication and hearing. The …