Mechanisms of chemotherapy-induced neurotoxicity
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …
Purinergic signalling in the gastrointestinal tract and related organs in health and disease
G Burnstock - Purinergic signalling, 2014 - Springer
Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …
Neonatal antibiotics have long term sex‐dependent effects on the enteric nervous system
Infants and young children receive the highest exposures to antibiotics globally. Although
there is building evidence that early life exposure to antibiotics increases susceptibility to …
there is building evidence that early life exposure to antibiotics increases susceptibility to …
[HTML][HTML] Enteric nervous system assembly: Functional integration within the developing gut
Co-ordinated gastrointestinal function is the result of integrated communication between the
enteric nervous system (ENS) and “effector” cells in the gastrointestinal tract. Unlike smooth …
enteric nervous system (ENS) and “effector” cells in the gastrointestinal tract. Unlike smooth …
Impact of probiotics on the prevention and treatment of gastrointestinal diseases in the pediatric population
JA García-Santos, A Nieto-Ruiz… - International Journal of …, 2023 - mdpi.com
Despite the high prevalence of gastrointestinal disorders (GIDs) in infants and children,
especially those categorized as functional GIDs (FGIDs), insufficient knowledge about their …
especially those categorized as functional GIDs (FGIDs), insufficient knowledge about their …
Properties of cholinergic and non‐cholinergic submucosal neurons along the mouse colon
Key points Submucosal neurons are crucial regulators of gut secretion. Despite significant
interest in using mouse models for enteric neuropathies, much is still unknown about their …
interest in using mouse models for enteric neuropathies, much is still unknown about their …
Impact of chemotherapy on gastrointestinal functions and the enteric nervous system
Chemotherapy is the main treatment for many cancers, including colorectal cancer, a type of
cancer with some of the highest prevalence and mortality rates worldwide. Although …
cancer with some of the highest prevalence and mortality rates worldwide. Although …
Load-bearing function of the colorectal submucosa and its relevance to visceral nociception elicited by mechanical stretch
Mechanical distension beyond a particular threshold evokes visceral pain from distal colon
and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception …
and rectum (colorectum), and thus biomechanics plays a central role in visceral nociception …
Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle‐associated epithelium and during stress in rats
ÅV Keita, AH Carlsson, M Cigehn… - …, 2013 - Wiley Online Library
Background Vasoactive intestinal polypeptide (VIP) has been implicated as a regulator of
intestinal barrier function and inflammation. Our aim was to elucidate the role of VIP in …
intestinal barrier function and inflammation. Our aim was to elucidate the role of VIP in …
Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine …
M Casado‐Bedmar, SDS Heil, P Myrelid… - …, 2019 - Wiley Online Library
Abstract Background Mast cells (MCs) and vasoactive intestinal polypeptide (VIP) have
been proposed as regulators of the intestinal barrier and inflammation. Our aim was to map …
been proposed as regulators of the intestinal barrier and inflammation. Our aim was to map …