Sterile inflammation: sensing and reacting to damage
Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors …
immune response to microorganisms, with the identification of pattern recognition receptors …
[HTML][HTML] Complement membrane attack complex: new roles, mechanisms of action, and therapeutic targets
The complement membrane attack complex (MAC) is classically known as a cytolytic effector
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …
of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or …
The importance of non-HLA antibodies in transplantation
Q Zhang, EF Reed - Nature Reviews Nephrology, 2016 - nature.com
The development of post-transplantation antibodies against non-HLA autoantigens is
associated with rejection and decreased long-term graft survival. Although our knowledge of …
associated with rejection and decreased long-term graft survival. Although our knowledge of …
Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E–deficient mice
E Smith, KMR Prasad, M Butcher, A Dobrian, JK Kolls… - Circulation, 2010 - Am Heart Assoc
Background—T cells play an important role during the immune response that accompanies
atherosclerosis. To date, the role for interleukin (IL)-17A in atherogenesis is not well defined …
atherosclerosis. To date, the role for interleukin (IL)-17A in atherogenesis is not well defined …
[HTML][HTML] FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression
Maintenance of normal endothelial function is critical to various aspects of blood vessel
function, but its regulation is poorly understood. In this study, we show that disruption of …
function, but its regulation is poorly understood. In this study, we show that disruption of …
Interleukin-17 and interferon-γ are produced concomitantly by human coronary artery–infiltrating T cells and act synergistically on vascular smooth muscle cells
Background—Atherosclerosis is an inflammatory disease in which interferon (IFN)-γ, the
signature cytokine of Th1 cells, plays a central role. We investigated whether interleukin (IL) …
signature cytokine of Th1 cells, plays a central role. We investigated whether interleukin (IL) …
Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
C Erbel, L Chen, F Bea, S Wangler, S Celik… - The Journal of …, 2009 - journals.aai.org
The importance of an (auto) immune response in atherogenesis is becoming increasingly
well understood. IL-17A-expressing T cells modulate immune cell trafficking, initiating …
well understood. IL-17A-expressing T cells modulate immune cell trafficking, initiating …
Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation
Y Zheng, M Humphry, JJ Maguire, MR Bennett… - Immunity, 2013 - cell.com
Necrosis can induce profound inflammation or be clinically silent. However, the mechanisms
underlying such tissue specificity are unknown. Interleukin-1α (IL-1α) is a key danger signal …
underlying such tissue specificity are unknown. Interleukin-1α (IL-1α) is a key danger signal …
Processes of sterile inflammation
Sterile inflammation occurs in acute conditions, such as ischemia reperfusion injury and
crystal-induced arthritis, as well as with chronic diseases, such as particle-induced lung …
crystal-induced arthritis, as well as with chronic diseases, such as particle-induced lung …
[HTML][HTML] Rosacea: the cytokine and chemokine network
Rosacea is one of the most common dermatoses of adults. Recent studies have improved
our understanding of the pathophysiology of rosacea. Current concepts suggest that known …
our understanding of the pathophysiology of rosacea. Current concepts suggest that known …