Cell death in the gut epithelium and implications for chronic inflammation

JV Patankar, C Becker - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Inflammatory responses and inflammation-associated diseases in organs

L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng… - …, 2017 - pmc.ncbi.nlm.nih.gov
Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice

B Li, Y Ding, X Cheng, D Sheng, Z Xu, Q Rong, Y Wu… - Chemosphere, 2020 - Elsevier
Environmental pollution caused by plastics has become a public health problem. However,
the effect of microplastics on gut microbiota, inflammation development and their underlying …

Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

Gut microbiota modulation of chemotherapy efficacy and toxicity

JL Alexander, ID Wilson, J Teare, JR Marchesi… - Nature reviews …, 2017 - nature.com
Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

Mechanisms and consequences of intestinal dysbiosis

GA Weiss, T Hennet - Cellular and Molecular Life Sciences, 2017 - Springer
The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer

D Yao, M Dong, C Dai, S Wu - Inflammatory bowel diseases, 2019 - academic.oup.com
Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Immune response and inflammatory pathway of ulcerative colitis

N Tatiya-Aphiradee, W Chatuphonprasert… - Journal of basic and …, 2018 - degruyter.com
Ulcerative colitis (UC) is an idiopathic relapsing inflammatory disease. Although the etiology
of UC remains unclear, it could be characterized by inflammation of the intestinal mucosa …