The pathogenesis of endometriosis: molecular and cell biology insights
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …
evolutionary biology. The recent development of cost-effective methods for obtaining high …
Haplotype-resolved genome assembly provides insights into evolutionary history of the tea plant Camellia sinensis
Tea is an important global beverage crop and is largely clonally propagated. Despite
previous studies on the species, its genetic and evolutionary history deserves further …
previous studies on the species, its genetic and evolutionary history deserves further …
High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …
contain more genetic variation than those from any other continent, yet only a fraction of the …
Durum wheat genome highlights past domestication signatures and future improvement targets
The domestication of wild emmer wheat led to the selection of modern durum wheat, grown
mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome …
mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome …
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …
heritability, shows differences in prevalence, severity and age of onset among different …
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Y Shi, S Fan, M Wu, Z Zuo, X Li, L Jiang, Q Shen… - Nature …, 2019 - nature.com
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …
A spectrum of free software tools for processing the VCF variant call format: vcflib, bio-vcf, cyvcf2, hts-nim and slivar
Since its introduction in 2011 the variant call format (VCF) has been widely adopted for
processing DNA and RNA variants in practically all population studies—as well as in …
processing DNA and RNA variants in practically all population studies—as well as in …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …