No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Groundbreaking advances in volume electron microscopy and specimen preparation are
enabling the 3-dimensional visualisation of specimens with unprecedented detail, and …

Advances in the scientific fields of photogrammetry and computer vision have led to the
development of automated multi-image methods that solve the problem of 3D reconstruction …

Electron microscopy (EM) has been a key imaging method to investigate biological
ultrastructure for over six decades. In recent years, novel volume EM techniques have …

A quiet revolution is under way in technologies used for nanoscale cellular imaging.
Focused ion beams, previously restricted to the materials sciences and semiconductor …

The interface between cells and nonbiological surfaces regulates cell attachment, chronic
tissue responses, and ultimately the success of medical implants or biosensors. Clinical and …

A major goal in materials science is to develop bioinspired functional materials based on the
precise control of molecular building blocks across length scales. Here we report a protein …

Focused ion beam microscopes are extremely versatile and powerful instruments for
materials research. These microscopes, when coupled in a system with a scanning electron …