Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …

Migraine with aura is a common but poorly understood sensory circuit disorder. Monogenic
models allow an opportunity to investigate its mechanisms, including spreading …

Abstract Lead ions (Pb 2+) possess characteristics similar to Ca 2+. Because of this and its
redox capabilities, lead causes different toxic effects. The neurotoxic effects have been well …

The Buthidae family of scorpions consists of arthropods with significant medical relevance,
as their venom contains a diverse range of biomolecules, including neurotoxins that …

How neurons in the eye feed signals back to photoreceptors to optimize sensitivity to
patterns of light appears to be mediated by one or more unconventional mechanisms. Via …

Cone snails are marine gastropod mollusks with one of the most powerful venoms in nature.
The toxins, named conotoxins, must act quickly on the cone snails´ prey due to the fact that …

Inspired by biological channels, metal‐organic framework (MOF) membranes with sub‐
nanometer sized channels offer an ideal platform to construct high‐performance artificial …

So-called pharmacoresistant (R-type) voltage-gated Ca 2+ channels are structurally only
partially characterized. Most of them are encoded by the CACNA1E gene and are expressed …