Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Myopia is the most common eye disorder, caused by heterogeneous genetic and
environmental factors. Rare progressive and stationary inherited retinal disorders are often …

Goldfish (Carassius auratus) have long fascinated evolutionary biologists and geneticists
because of their diverse morphological and color variations. Recent genome-wide …

To effectively reduce vision loss due to age-related macular generation (AMD) on a global
scale, knowledge of its genetic architecture in diverse populations is necessary. A critical …

The retinal pigment epithelium (RPE) is a highly specialised pigmented monolayer
sandwiched between the choroid and the photoreceptors in the retina. Key functions of the …

Megalin is an endocytic receptor abundantly expressed in proximal tubular epithelial cells
and other calciotropic extrarenal cells expressing vitamin D metabolizing enzymes, such as …

To fulfill their multiple roles in organ development and adult tissue homeostasis, hedgehog
(HH) morphogens act through their receptor Patched (PTCH) on target cells. However, HH …

Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic
development and adult tissue homeostasis. Loss of this receptor in congenital or acquired …

We show that the multiligand receptor megalin, known to mediate uptake and trafficking of
nutrients and signaling molecules, is frequently expressed in malignant melanoma samples …

Pathogenic variants in the LRP2 gene, encoding the multiligand receptor megalin, cause a
rare autosomal recessive syndrome: Donnai-Barrow/Facio-Oculo-Acoustico-Renal …