During the millions of years they have coexisted with their hosts, viruses have learned how
to manipulate host immune control mechanisms. Viral gene functions provide an overview of …

Large DNA viruses defend against hostile assault executed by the host immune system by
producing an array of gene products that systematically sabotage key components of the …

Viruses have evolved elegant mechanisms to evade detection and destruction by the host
immune system. One of the evasion strategies that have been adopted by large DNA viruses …

This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Publisher Summary This chapter focuses on the advances in iridovirus research over the
past decade. It summarizes salient features of the iridovirus research studies, and discusses …

Human cytomegalovirus (CMV) remains the major infectious cause of birth defects as well
as an important opportunistic pathogen. Individuals infected with CMV mount a strong …

Myxomatosis in European rabbits is a severely debilitating disease characterized by
profound systemic cellular immunosuppression and a high rate of mortality. The causative …

Successful transmission by viruses in the face of vigorous innate and acquired host
immunity requires the ability to evade, obstruct, or subvert critical elements that mediate host …

Many cytokines are known to play a role in host defense against viral infections (Thomson,
1998). While cytokines, such as interferon (IFN)-/, IFN-, and tumor necrosis factor (TNF) …

Chemokines are a family of small proteins that interact with seven-transmembrane domain
receptors and modulate the migration of immune cells into sites of inflammation and …