Progress and Challenges in the Field of Snakebite Envenoming Therapeutics
JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
Recombinant snake antivenoms get closer to the clinic
AH Laustsen - Trends in immunology, 2024 - cell.com
Snakebite envenomings kill~ 100 000 victims each year and leave many more with
permanent sequelae. Antivenoms have been available for more than 125 years but are in …
permanent sequelae. Antivenoms have been available for more than 125 years but are in …
[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Immunoglobulin G (IgG) antibodies that bind their cognate antigen in a pH-dependent
manner (acid-switched antibodies) can release their bound antigen for degradation in the …
manner (acid-switched antibodies) can release their bound antigen for degradation in the …
[HTML][HTML] Improving in vivo assays in snake venom and antivenom research: A community discussion
On the 26 th January 2023, a free to attend,'improving in vivo snake venom research: a
community discussion'meeting was held virtually. This webinar brought together researchers …
community discussion'meeting was held virtually. This webinar brought together researchers …
[HTML][HTML] Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera
Despite the considerable global impact of snakebite envenoming, available treatments
remain suboptimal. Here, we report the discovery of a broadly-neutralizing human …
remain suboptimal. Here, we report the discovery of a broadly-neutralizing human …
De novo designed proteins neutralize lethal snake venom toxins
S Vázquez Torres, M Benard Valle, SP Mackessy… - Nature, 2025 - nature.com
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over
100,000 lives annually and causing severe complications and long-lasting disabilities for …
100,000 lives annually and causing severe complications and long-lasting disabilities for …
De novo designed proteins neutralize lethal snake venom toxins
SV Torres, MB Valle, SP Mackessy… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over
100,000 lives annually and causing severe complications and long-lasting disabilities for …
100,000 lives annually and causing severe complications and long-lasting disabilities for …
The potential risks of equine serum therapy in transmitting new infectious diseases: lessons from a post-pandemic era
MB Pucca, AL Camphora - Frontiers in Public Health, 2024 - frontiersin.org
In the world of medical treatments, certain interventions carry hidden risks that are not
always readily apparent. The use of equine serum in human therapies has raised …
always readily apparent. The use of equine serum in human therapies has raised …