Hepatocellular carcinoma surveillance—Utilization, barriers and the impact of changing aetiology

DQ Huang, AG Singal, F Kanwal… - Nature Reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …

Natural history and progression of metabolic dysfunction-associated steatotic liver disease

H Hagström, Y Shang, H Hegmar… - … Lancet Gastroenterology & …, 2024 - thelancet.com
The natural history of metabolic dysfunction-associated steatotic liver disease (MASLD),
previously referred to as non-alcoholic fatty liver disease (NAFLD), is complex and long. A …

Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease

ZM Younossi, SA Alqahtani, K Alswat, Y Yilmaz… - Journal of …, 2024 - Elsevier
Background & Aims Patients with fatty liver disease may experience stigma from the disease
or comorbidities. In this cross-sectional study, we aimed to understand stigma among …

[HTML][HTML] Management of metabolic-associated fatty liver disease/metabolic dysfunction-associated steatotic liver disease: from medication therapy to nutritional …

M Beygi, S Ahi, S Zolghadri, A Stanek - Nutrients, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a common long-lasting liver disease that affects
millions of people around the world. It is best identified with a hepatic fat build-up that …

[HTML][HTML] Denifanstat for the treatment of metabolic dysfunction-associated steatohepatitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2b trial

R Loomba, P Bedossa, K Grimmer… - The Lancet …, 2024 - thelancet.com
Background Denifanstat, an oral fatty acid synthase (FASN) inhibitor, blocks de-novo
lipogenesis, a key pathway driving progressive lipotoxicity, inflammation, and fibrosis in …

[HTML][HTML] Nutrition could prevent or promote non-alcoholic fatty liver disease: An opportunity for intervention

M Romero-Gómez, S Zelber-Sagi, F Martín… - bmj, 2023 - bmj.com
Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for
intervention | The BMJ Skip to main content Intended for healthcare professionals Access …

Outcomes of various classes of oral antidiabetic drugs on nonalcoholic fatty liver disease

H Jang, Y Kim, DH Lee, SK Joo, BK Koo… - JAMA Internal …, 2024 - jamanetwork.com
Importance Several oral antidiabetic drug (OAD) classes can potentially improve patient
outcomes in nonalcoholic fatty liver disease (NAFLD) to varying degrees, but clinical data on …

The synergistic impact of type 2 diabetes and MASLD on cardiovascular, liver, diabetes‐related and cancer outcomes

DR Riley, T Hydes, G Hernadez, SS Zhao… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims We examined the impact of a co‐diagnosis of metabolic
dysfunction‐associated steatotic liver disease (MASLD) and type 2 diabetes (T2D) on …

The pathophysiology of MASLD: an immunometabolic perspective

J Schwärzler, F Grabherr, C Grander… - Expert review of …, 2024 - Taylor & Francis
Introduction Metabolic-associated liver diseases have emerged pandemically across the
globe and are clinically related to metabolic disorders such as obesity and type 2 diabetes …

Meeting at the crossroad between obesity and hepatic carcinogenesis: unique pathophysiological pathways raise expectations for innovative therapeutic approaches

K Arvanitakis, SP Papadakos, V Lekakis… - International Journal of …, 2023 - mdpi.com
The escalating global prevalence of obesity and its intricate association with the
development of hepatocellular carcinoma (HCC) pose a substantial challenge to public …