The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but
remains less explored in peripheral tissues. Exercise training activates kynurenine …

The naturally occurring polyamine spermidine (Spd) has recently been shown to promote
longevity across species in an autophagy-dependent manner. Here, we demonstrate that …

Regulators of G-protein-signaling (RGS) proteins are a category of intracellular proteins that
have an inhibitory effect on the intracellular signaling produced by G-protein-coupled …

We analyzed genome-wide association studies (GWASs), including data from 71,638
individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of …

Enhanced exercise capacity is not only a feature of healthful aging, but also a therapy for
aging patients and patients with cardiovascular disease. Disruption of the Regulator of G …

Pigmentation varies within and between species and is often adaptive. The amount of
pigmentation on the abdomen of Drosophila melanogaster is a relatively simple …

Spermidine is a natural polyamine involved in many important cellular functions, whose
supplementation in food or water increases life span and stress resistance in several model …

Biological behaviors and longevity of ectothermic animals are remarkably influenced by
ambient temperature. Development at 18 C significantly enhances the stress resistance of …

Thioacetamide (TAA) was administered orally at 0, 10, and 30 mg/kg body weight (BW) daily
to Sprague–Dawley rats aged 6–7 weeks for 28 consecutive days. Nephrotoxicity and …

The Greatwall-family protein kinase Rim15 is associated with the nutrient starvation
response, whereas its role in oxidative stress responses remains unclear. Here, acetic acid …