Review of the current state of protein aggregation inhibition from a materials chemistry perspective: Special focus on polymeric materials

R Rajan, S Ahmed, N Sharma, N Kumar, A Debas… - Materials …, 2021 - pubs.rsc.org
Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Modulation of amyloid protein fibrillation by synthetic polymers: Recent advances in the context of neurodegenerative diseases

P Ghosh, P De - ACS Applied Bio Materials, 2020 - ACS Publications
Protein misfolding and aggregation have attracted immense research interests due to their
connection with an array of degenerative diseases including neurodegenerative disorders …

Stimuli-responsive zwitterionic core–shell microgels for antifouling surface coatings

P Saha, M Santi, M Emondts, H Roth… - … Applied Materials & …, 2020 - ACS Publications
Fouling on filtration membranes is induced by the nonspecific interactions between the
membrane surface and the foulants, and effectively hinders their efficient use in various …

Facile photolithographic fabrication of zwitterionic polymer microneedles with protein aggregation inhibition for transdermal drug delivery

H Pitakjakpipop, R Rajan, K Tantisantisom… - …, 2021 - ACS Publications
Microneedle technology has received considerable attention in transdermal drug delivery
system research owing to its minimally invasive and convenient self-administration with …

Design of an Ice Recrystallization-Inhibiting Polyampholyte-Containing Graft Polymer for Inhibition of Protein Aggregation

R Rajan, N Kumar, K Matsumura - Biomacromolecules, 2021 - ACS Publications
Freezing-induced damage to proteins, through osmotic stress and ice recrystallization,
during protein processing and long-term storage is a serious concern and may lead to loss …

Dual thermo-and pH-responsive behavior of double zwitterionic graft copolymers for suppression of protein aggregation and protein release

D Zhao, R Rajan, K Matsumura - ACS applied materials & …, 2019 - ACS Publications
Graft copolymers consisting of two different zwitterionic blocks were synthesized via
reversible addition fragmentation chain transfer polymerization. These polymers showed …

Dual-temperature-responsive microgels from a zwitterionic functional graft copolymer with superior protein repelling property

P Saha, M Santi, M Frenken, AR Palanisamy… - ACS Macro …, 2020 - ACS Publications
In this work, we developed a synthetic strategy to synthesize dual-temperature-responsive
low surface fouling zwitterionic microgels. Statistical poly (N-vinylcaprolactam-co-glycidyl …

“Smart” composite microneedle patch stabilizes glucagon and prevents nocturnal hypoglycemia: Experimental studies and molecular dynamics simulation

B Lu, A GhavamiNejad, JF Liu, J Li… - … Applied Materials & …, 2022 - ACS Publications
Hypoglycemia is a major complication associated with insulin therapy in people with
diabetes that could cause life-threatening conditions if untreated. Glucagon, a counter-acting …

Modulating insulin aggregation with charge variable cholic acid-derived polymers

A Bera, S Sahoo, K Goswami, SK Das… - …, 2021 - ACS Publications
To understand the effect of cholic acid (CA)-based charge variable polymeric architectures
on modulating the insulin aggregation process, herein, we have designed side-chain …

Functional zwitterionic biomaterials for administration of insulin

X Chen, D Yang - Biomaterials Science, 2020 - pubs.rsc.org
Insulin administration is necessary for patients with type 1 diabetes and advanced type 2
diabetes. However, there are many drawbacks associated with it, such as hypoglycemia and …