Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living
organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell …

Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Polyamines are ubiquitous small basic molecules that play multiple essential roles in
mammalian physiology. Their cellular content is highly regulated and there is convincing …

Polyamines are aliphatic compounds with more than two amino groups that play various
important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs …

The epithelium of gastrointestinal (GI) mucosa has the most rapid turnover rate of any tissue
in the body and its integrity is preserved through the dynamic balance between cell …

Abstract Camptothecin (CPT) and Nutlin-3 caused apoptosis by increasing p53 protein and
its activation in intestinal epithelial cells (IEC-6). We studied the effectiveness of these …

Purpose.: Relatively little is known about the contribution of p53/Mdm2 pathway in apoptosis
of retinal pigment epithelial (RPE) cells or its possible link to dysfunction of aging RPE or to …

The polyamines putrescine, spermidine and spermine are intimately involved in the
regulation of cellular growth and viability. Transduction of human embryonic kidney (HEK) …

The Raf-MEK-ERK pathway is commonly activated in human cancers, largely attributable to
the extracellular signal-regulated kinases (ERKs) being a common downstream target of …

It has been shown previously that nutritional supplements rich in polyphenolic compounds
play a significant role in prostate cancer chemoprevention. Propolis is a natural, resinous …